FIG 1.

Histologic damage and luminal fluid accumulation in colonic loops treated with CPE (25 μg/ml, 50 μg/ml, or 100 μg/ml) or HBSS buffer alone. (A) Colonic histopathology damage after a 6-h treatment with the indicated CPE doses. Results shown are the mean ± standard deviation (SD) for six rabbits. Histologic damage severity was based on a five-point scale, with 5 representing the most severe damage (see Materials and Methods). * or ** denotes a significant difference compared to the buffer control (P < 0.05 or P < 0.001, respectively). (B) Luminal fluid accumulation (g/cm) after a 6-h treatment with the specified CPE dose. Results shown are the mean ± SD for six rabbits. * denotes a significant difference compared to the buffer control (P < 0.05).