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3-His metal center of Dke1 and hydrophilic active site residues, Tyr70, Arg80, Glu98 and Thr107 (PDB: 3BAL) [70]. The metal ion in the structure, which is Zn(II), is shown in orange, water molecules are in slate blue, oxygen atoms and nitrogen atoms are in red and blue, respectively. H-bonds are indicated as slate blue dashed lines. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.)
