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. 2013 Jan 15;257(2):541–563. doi: 10.1016/j.ccr.2012.04.028

Fig. 14.

Fig. 14

Reaction mechanism of diketone cleavage by Dke1. As the initially proposed reaction mechanism via a dioxetane intermediate (path 1, dashed arrows) [77] is high in energy, an alternative, energetically more feasible C—C bond cleavage mechanism has been proposed based on DFT calculations (path 2) [79].