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Dose-dependent effect of duloxetine on PNS-induced inhibition of bladder overactivity caused by AA irritation. The CMGs were performed in sequence from left to right (A–C) and from top to bottom in each figure. PNS duration is indicated by black bar under bladder pressure trace. T, PNS threshold intensity for inducing anal sphincter twitch. (A) Control CMGs without PNS. (B) CMGs during 2T PNS. (C) CMGs during 4T PNS. PNS, 5 Hz, 0.2 milliseconds. T = 1 V. Infusion rate = 2 ml/min.
