Table 4.
Relationship Between Changes in Biochemical Markers of Bone Turnover and Histomorphometric Indices With PTH(1–84) Treatment
| Increase in histomorphometric parameter |
Predicted by increase in turnover marker |
R2 | Slope (β) | p Value | |
|---|---|---|---|---|---|
| Quadruple label (3 months) | Cancellous Md.Pm | P1NP | 0.51 | 0.102 ± 0.03 | < 0.01 |
| TRAP | 0.50 | 3.04 ± 0.96 | 0.01 | ||
| Cancellous BFR | P1NP | 0.36 | 0.001 ± 0.01 | 0.04 | |
| TRAP | 0.45 | 0.024 ± 0.01 | 0.02 | ||
| 12-Month repeat biopsy | Cancellous Md.Pm | P1NP | 0.54 | 0.056 ± 0.02 | 0.01 |
| BAP | 0.34 | 0.192 ± 0.08 | 0.05 | ||
| CTX | 0.41 | 6.75 ± 2.53 | 0.02 | ||
| TRAP | 0.50 | 0.689 ± 0.22 | 0.01 | ||
| Cancellous MAR | BAP | 0.36 | 0.007 ± 0.01 | 0.04 | |
| Cancellous BFR | P1NP | 0.52 | 0.001 ± 0.01 | 0.01 | |
| BAP | 0.33 | 0.002 ± 0.01 | 0.05 | ||
| CTX | 0.41 | 0.066 ± 0.03 | 0.03 | ||
| TRAP | 0.46 | 0.007 ± 0.01 | 0.02 | ||
| Endocortical MAR | OCN | 0.39 | 0.002 ± 0.01 | 0.03 | |
| 24-Month repeat biopsy | BV/TV | P1NP | 0.41 | 0.071 ± 0.02 | 0.01 |
| BAP | 0.36 | 0.326 ± 0.12 | 0.02 | ||
| Cancellous Md.Pm | P1NP | 0.37 | 0.04 ± 0.01 | 0.02 | |
| OCN | 0.37 | 0.219 ± 0.08 | 0.02 | ||
| CTX | 0.44 | 4.302 ± 1.35 | <0.01 | ||
| TRAP | 0.50 | 2.197 ± 0.61 | <0.01 | ||
| Cancellous BFR | P1NP | 0.40 | 0.001 ± 0.01 | 0.01 | |
| OCN | 0.37 | 0.002 ± 0.01 | 0.02 | ||
| CTX | 0.42 | 0.039 ± 0.01 | <0.01 | ||
| TRAP | 0.53 | 0.021 ± 0.01 | <0.01 | ||
| Endocortical Md.Pm | CTX | 0.83 | 7.884 ± 0.98 | <0.0001 | |
| Endocortical BFR | CTX | 0.87 | 0.078 ± 0.01 | <0.0001 |