Open Label
	RCT Baseline* (n=498)	Open Label Baseline** (n=497)†	Month 3 (n=491)	Month 6 (n=464)	Month 9 (n=454)
From 3-day voiding diaries ∞
Urgency incontinence episodes per day†
Adjusted means [standard errors (SE)]	3.90 (0.11)	1.75 (0.11)	1.08 (0.11)	0.97 (0.11)	0.95 (0.11)
Median (IQR)F̄	3.0 (2.0-5.0)	1.0 (0.0-2.3)	0.3 (0.0-1.3)	0.3 (0.0-1.0)	0.3 (0.0-1.0)
Total incontinence episodes per day
Adjusted means (SE)	4.64 (0.12)	2.11 (0.13)	1.36 (0.13)	1.22 (0.13)	1.16 (0.13)
Median (IQR)	3.7 (2.3-6.0)	1.0 (0.3-2.7)	0.7 (0.0-1.7)	0.3 (0.0-1.3)	0.3 (0.0-1.3)
Daytime incontinence episodes per day
Adjusted means (SE)	4.03 (0.11)	1.84 (0.11)	1.19 (0.11)	1.09 (0.11)	1.06 (0.11)
Median (IQR)	3.2 (2.0-5.0)	1.0 (0.3-2.3)	0.3 (0.0-1.7)	0.3 (0.0-1.3)	0.3 (0.0-1.3)
Daytime voiding episodes per day
Adjusted means (SE)	8.67 (0.14)	7.99 (0.14)	7.59 (0.14)	7.67 (0.14)	7.70 (0.14)
Median (IQR)	8.3 (6.7-10.0)	7.7 (6.3-9.3)	7.3 (6.0-9.0)	7.3 (6.0-8.7)	7.3 (5.8-9.2)
Nocturnal voiding episodes per night¥
Adjusted means (SE)	1.24 (0.05)	0.89 (0.05)	0.75 (0.05)	0.75 (0.05)	0.74 (0.05)
Median (IQR)	1.0 (0.3-2.0)	0.7 (0.0-1.3)	0.3 (0.0-1.3)	0.3 (0.0-1.3)	0.3 (0.0-1.2)
Moderate urgency-associated voids per day‡
Adjusted means (SE)	7.65 (0.20)	5.76 (0.20)	5.07 (0.20)	4.87 (0.20)	4.96 (0.20)
Median (IQR)	6.7 (4.7-9.7)	5.0 (2.3-8.0)	4.7 (1.7-7.3)	4.3 (1.7-6.7)	4.3 (2.0-7.0)
Severe urgency-associated voids per day§
Adjusted means (SE)	3.44 (0.12)	1.90 (0.12)	1.29 (0.12)	1.30 (0.13)	1.38 (0.13)
Median (IQR)	2.3 (1.0-4.7)	0.7 (0.0-2.7)	0.7 (0.0-1.7)	0.3 (0.0-1.7)	0.7 (0.0-1.7)
Self-report Bladder-specific questionnaires
Overactive Bladder Questionnaire score¶
Adjusted means (SE)	36.70 (0.85)	21.65 (0.85)	15.39 (0.85)	14.90 (0.86)	14.86 (0.86)
Median (IQR)	33.6 (21.8-47.3)	15.8 (6.7-31.5)	9.7 (3.6-20.0)	9.1 (3.6-18.8)	8.5 (3.6-18.8)
Patient Perception of Bladder Condition score∥
Adjusted means (SE)	3.04 (0.06)	2.12 (0.06)	1.52 (0.06)	1.49 (0.06)	1.44 (0.06)
Median (IQR)	3.0 (2.0-4.0)	2.0 (1.0-3.0)	1.0 (1.0-2.0)	1.0 (0.0-2.0)	1.0 (0.0-2.0)
Patient Perception of Urgency Scale score±
Adjusted means (SE)	1.38 (0.03)	1.01 (0.03)	0.86 (0.03)	0.80 (0.03)	0.80 (0.03)
Median (IQR)	1.0 (1.0-2.0)	1.0 (1.0-1.0)	1.0 (0.0-1.0)	1.0 (0.0-1.0)	1.0 (0.0-1.0)

^*Randomized Control Trial (RCT): the pre-randomization visit of the 12-week RCT.

^**Baseline Open Label bladder diaries included data on RCT participants that had been on fesoterodine or placebo, all comparisons are significant at p<0.001 compared to the initial RCT visit.

⁺One participant failed show for the Baseline Open Label visit, but was enrolled in open label at the subsequent visit.

^∞Values reflect events per day based on participant completion of a 3-day voiding diary.

^†Self report on diary as an urgency or stress incontinence episode.

^F̄Interquartile range (IQR), Medians are unadjusted

^¥Self report on the diary as to the time the participant went to bed for the evening and when the participant woke in the morning.

^‡Moderate urgency-associated voids were defined as voiding episodes associated with at least a “moderate” sensation of urgency on voiding diary.

^§Severe urgency-associated voids were defined as voiding episodes associated with a “severe” sensation of urgency on voiding diary.

^¶Overactive Bladder Questionnaire scores range from 0 to 100, with higher scores indicating more severe or bothersome overactive bladder symptoms.^13,14

^∥Patient Perception of Bladder Condition scores range from 1 to 6, with higher scores indicating more severe bladder-related problems.¹⁴

^±Patient Perception of Urgency Scale scores range from 1 to 3, with higher scores indicating greater urgency.¹⁵