Fig. 3.

Gap junctional communication in human tenocytes treated with nonspecific gap junction blockers glycyrrhetinic acid (GA) and carbenoxolone disodium (CBX). Both GA and CBX disrupt gap junctional communication in tendon cells. (a) The mobile fraction percentage values in cells treated with 100-μM GA and vehicle control. Results shown are $\text{mean}\pm \mathrm{SEM}$ of three patients. Statistical differences are indicated as ***$p<0.001$. (b) The mobile fraction percentage values in tenocytes incubated with and without 100-μM CBX. Results shown are $\text{mean}\pm \mathrm{SD}$ of each tissue donor. Significant statistical differences were noted for all three donors with $p<0.001$ for patients 1 and 2 and $p<0.01$ for patient 3.