Table 4.
Effects of metal salts on the yields of the annulated pyridine 3 and substituted indole 4. a
| |||
|---|---|---|---|
| entry | metal | 3 | 4 |
| 1 | none | 73 | 64 |
| 2 | ZnCl2b | 51 | 42 |
| 3 | ZnCl2c | 0 | 0 |
| 4 | CuI | 53 | 49 |
| 5 | CuOAc | 54 | 50 |
| 6 | CuBr-SMe2 | 52 | 47 |
| 7 | NiCl2 | 42 | NDd |
| 8 | Nil2(PPh3)2 | 47 | NDd |
| 9 | Ni(COD)2 | 45 | NDd |
Conditions: substrate (0.15 mmol); metal salts (10 mol %) NaSO2CF3 (3 equiv); TBHP (5 equiv); TPGS-750-M:water (2 wt. %),
TMEDA (1 equiv),
1,10-Phen (1 equiv),
Not Determined.