Table 2. Imaging findings from all patients.

No difference in the apparent diffusion coefficient (ADC) between the time-to-peak (TTP) region and penumbra tissue was noted (P = 0.25), whereas significantly lower ADC was measured in both the ischemic core and tissue progressing to infarction (P < 0.001). There was no significant difference of the TTP or the T2 FLuid Attenuated Inversion Recovery (T2 FLAIR) data between any of the four regions. Finally, a trend for a mean reduction in amide proton transfer (APT) was found between the at-risk tissue and final infarct volume (P = 0.10), and all ischemic regions had lower APT effects relative to normal-appearing-white-matter (NAWM).

	Volume (mL)			ADC (a.u.)				TTP (s)				APT (Lorentzian)
Patient ID	Core	TTP Lengthening	Final Infarct	Core	TTP Lengthening	Final Infarct	NAWM	Core	TTP Lengthening	Final Infarct	NAWM	Core	TTP Lengthening	Final Infarct	NAWM
1	34.3	174.5	11.2	506	952	222	771	28.9	23.9	35.8	10.7	0.038	0.022	0.020	0.056
2	0.5	0.0	0.4	511	NA	278	764	8.8	NA	8.6	8.9	0.013	NA	0.008	0.028
3	6.8	35.9	NA	441	959	NA	782	27.4	28.5	NA	22.7	0.054	0.059	NA	0.052
4	5.2	194.4	138.7	444	1132	981	754	19.2	15.7	15.9	8.3	0.034	0.030	0.033	0.039
5	0.6	0.0	1.2	549	NA	705	833	7.7	NA	8.0	6.0	0.052	NA	0.056	0.049
6	51.3	186.0	NA	576	1136	NA	864	30.6	23.4	NA	9.9	0.043	0.033	NA	0.062
7	3.3	19.5	1.7	518	1171	1038	761	15.2	22.9	25.9	14.9	0.039	0.045	0.043	0.048
8	0.6	0.2	0.0	542	563	NA	782	11.7	13.1	NA	9.6	0.031	0.010	NA	0.056
9	7.3	18.6	4.8	511	1013	745	795	13.6	23.0	14.3	11.7	0.024	0.029	0.024	0.037
10	0.947	0.183	1.663	348.07	523.6	449.8	770.8	12.86	14.58	12.67	11.32	0.023	0.039	0.026	0.059