Table 1. Clinico-pathological Characteristics of Patient Cohorts.
The Cancer Genome Atlas is a publicly available data base that contains DNA methylation data for hundreds of primary Non-Small Cell Lung Cancer (NSCLC) patients. Cohort A consists of resected NSCLC patients from Johns Hopkins Hospital in Baltimore, MD. Cohort B consists of resected NSCLC patients from Shinshu University Hospital in Matsumoto, Japan.
| Cohort | ||||
|---|---|---|---|---|
|
| ||||
| TCGA (n = 636) | A (n = 59) | B (n = 30) | ||
| Age | Average (years) | 68 | 65.8 | 64.1 |
|
| ||||
| Sex | F (%) | 238 (37.4%) | 27 (45.8%) | 11 (36.7%) |
| M (%) | 306 (48.1%) | 32 (54.2%) | 19 (63.3%) | |
| NA | 92 (14.5%) | 0 | 0 | |
|
| ||||
| Smoking | Ever | 466 (73.3%) | 47 (79.7%) | NA |
| Never | 61 (9.6%) | 4 (6.8%) | NA | |
| NA | 109 (17.1%) | 8 (13.6%) | NA | |
| Histology | Adeno | 409 (64.3%) | 36 (61.0%) | 21 (70%) |
| SCC | 227 (35.7%) | 23 (39.0%) | 9 (30%) | |
|
| ||||
| Stage | Ia | 125 (19.7%) | 16 (27.1%) | 3 (10%) |
| Ib | 159 (25.0%) | 20 (33.9%) | 4 (13.3%) | |
| IIa | 58 (9.1%) | 1 (1.7%) | 3 (10%) | |
| IIb | 84 (13.2%) | 9 (15.3%) | 6 (20%) | |
| IIIa | 78 (12.2%) | 7 (11.9%) | 7 (23.3%) | |
| IIIb | 14 (2.2%) | 3 (5.1%) | 4 (13.3%) | |
| IV | 17 (2.7%) | 3 (5.1%) | 3 (10%) | |
| NA | 101 (15.9%) | 0 | 0 | |