Table 3. Genes involved in penicillin biosynthesis and associated with rearrangement breakpoints.
Gene ID | Annotation (from Harris et. al. 2009) | Event # |
Pc12g00460 | strong similarity to multidrug resistance protein fnx1p – S. pombe | 12 |
Pc12g01540 | strong similarity to sulfate permease SutB – P. chrysogenum | 17 |
Pc18g03010 | strong similarity to choline permease Hnm1 – S. cerevisiae | 267 |
Pc18g03120 | strong similarity to hypothetical protein mg00375.1 – M. grisea | 269 |
Pc21g09650 | weak similarity to ecto-ATPase c-cam105 – R. norvegicus | 317 |
Pc21g13940 | strong similarity to hypothetical protein An03g01270 – A. niger | 318 |
Pc21g13950 | strong similarity to aspergillopepsin II – A. niger | 318 |
Pc22g09350 | strong similarity to vacuolar H(+) Ca(2+) exchanger Vcx1 – S. cerevisiae | 231 |
These genes are located within 5 kb of rearrangement breakpoints and have putative functions related to penicillin biosynthesis based on an expression profiling experiment performed by Harris et al (2009).