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. 2014 May 13;9(5):e97177. doi: 10.1371/journal.pone.0097177

Figure 6. Delphinidin suppresses the expression of major osteoclastogenic molecules in osteoclast precursor cells.

Figure 6

(A) Quantification of NF-κB DNA-binding activity in control cells, agent stimulated cells and delphinidin-treated cells. RANKL-stimulated NF-κB DNA-binding activity was significantly inhibited by delphinidin treatment (*p<0.001). (B) RT-PCR and (C) qPCR analysis of the expression of osteoclastogenic transcriptional genes, c-fos and Nfatc1, and osteoclast marker genes, Dc-stamp, Mmp9, Ctsk and Trap, in RAW264.7 cells.