Figure 6. sEH inhibition prevented type 2 diabetic-induced increases in infarct size following MCAO.

Control and HFD+STZ/NA mice were treated with the sEH inhibitor t-AUCB (1 mg/kg i.p. daily, 7 days) or vehicle and subjected to middle cerebral artery occlusion (60 min). Brains were harvested at 24 h post-MCAO, and infarct size measured by TTC staining and corrected for edema as described in methods. A) Representative images of infarct size in each treatment group. B) Infarct size is shown for separately for cortex, striatum, and total hemisphere. *p<0.05 vs. Control Vehicle, #p<0.05 vs. HFD+STZ/NA Vehicle, N = 8–10 per group.