Table 2. Association of studied polymorphisms with ROA in the total material and by occupation.
Gene | Chr | SNP | MAF (%) | Group | MAF (%) Our study | HWE | ROA | |||||
NCBI | HapMap | Total | Case | Control | (p-value) | OR | 95% CI | p-value | ||||
Replication analyses | ||||||||||||
A2BP1 | 16 | rs716508 | 39 | 28 | All | 35 | 31 | 36 | 0.09 | 0.68 | 0.50–0.93 | 0.01 |
Dentists | 35 | 33 | 36 | 0.69 | 0.39–1.23 | 0.19 | ||||||
Teachers | 34 | 28 | 37 | 0.58 | 0.34–1.01 | 0.05 | ||||||
COG5 | 7 | rs3757713 | 14 | 21 | All | 19 | 20 | 18 | 0.07 | 1.16 | 0.83–1.63 | 0.38 |
Dentists | 19 | 23 | 18 | 1.60 | 0.90–2.86 | 0.09 | ||||||
Teachers | 18 | 18 | 18 | 0.97 | 0.54–1.75 | 0.92 | ||||||
COG5 | 7 | rs3815148 | 19 | 22 | All | 19 | 20 | 18 | 0.12 | 1.14 | 0.81–1.59 | 0.45 |
Dentists | 19 | 24 | 18 | 1.51 | 0.84–2.71 | 0.11 | ||||||
Teachers | 18 | 17 | 18 | 0.90 | 0.50–1.62 | 0.74 | ||||||
GDF5 | 20 | rs143383 | 29 | 32 | All | 43 | 41 | 43 | 0.55 | 0.93 | 0.70–1.22 | 0.58 |
Dentists | 43 | 40 | 44 | 0.80 | 0.44–1.43 | 0.49 | ||||||
Teachers | 42 | 42 | 42 | 1.21 | 0.68–2.14 | 0.51 | ||||||
HFE | 6 | rs1799945 | 8 | 18 | All | 13 | 13 | 12 | 0.53 | 1.15 | 0.76–1.74 | 0.52 |
Dentists | 12 | 10 | 12 | 0.86 | 0.43–1.74 | 0.68 | ||||||
Teachers | 14 | 15 | 13 | 1.55 | 0.84–2.88 | 0.19 | ||||||
ESR1 | 6 | rs2234693 | 44 | 41 | All | 40 | 39 | 41 | 0.60 | 0.94 | 0.71–1.24 | 0.67 |
Dentists | 41 | 40 | 41 | 0.80 | 0.45–1.43 | 0.45 | ||||||
Teachers | 40 | 39 | 40 | 1.08 | 0.62–1.89 | 0.82 | ||||||
ESR1 | 6 | rs9340799 | 26 | 30 | All | 25 | 26 | 25 | 0.20 | 1.05 | 0.76–1.45 | 0.78 |
Dentists | 27 | 26 | 27 | 0.83 | 0.47–1.45 | 0.51 | ||||||
Teachers | 24 | 26 | 23 | 1.62 | 0.94–2.79 | 0.08 | ||||||
Exploratory analyses | ||||||||||||
PTGS2 | 1 | rs4140564 | 4 | 8 | All | 7 | 6 | 7 | 0.35 | 0.90 | 0.50–1.61 | 0.72 |
Dentists | 6 | 3 | 7 | 0.40 | 0.13–1.21 | 0.08 | ||||||
Teachers | 8 | 9 | 7 | 1.44 | 0.69–3.02 | 0.33 | ||||||
PARD3B | 2 | rs1207421 | 13 | 9 | All | 10 | 11 | 9 | 1.00 | 1.04 | 0.66–1.64 | 0.87 |
Dentists | 10 | 12 | 9 | 1.17 | 0.59–2.33 | 0.67 | ||||||
Teachers | 10 | 10 | 9 | 0.90 | 0.45–1.82 | 0.80 | ||||||
DVWA | 3 | rs7639618 | 26 | 18 | All | 16 | 16 | 16 | 0.95 | 1.11 | 0.76–1.63 | 0.58 |
Dentists | 18 | 19 | 17 | 1.52 | 0.84–2.76 | 0.16 | ||||||
Teachers | 14 | 14 | 14 | 0.82 | 0.44–1.52 | 0.57 | ||||||
HLA | 6 | rs10947262 | 17 | 6 | All | 14 | 15 | 14 | 0.68 | 1.06 | 0.72–1.56 | 0.78 |
Dentists | 15 | 16 | 14 | 1.10 | 0.59–2.05 | 0.82 | ||||||
Teachers | 14 | 14 | 14 | 1.01 | 0.54–1.89 | 0.99 | ||||||
BCAP29 | 7 | rs10953541 | 14 | 27 | All | 26 | 27 | 25 | 0.18 | 1.09 | 0.81–1.48 | 0.58 |
Dentists | 27 | 29 | 26 | 1.43 | 0.81–2.51 | 0.18 | ||||||
Teachers | 24 | 25 | 24 | 1.06 | 0.61–1.83 | 0.78 | ||||||
DUS4L | 7 | rs4730250 | 12 | 17 | All | 15 | 17 | 15 | 0.23 | 1.15 | 0.80–1.66 | 0.46 |
Dentists | 16 | 20 | 14 | 1.63 | 0.89–2.97 | 0.10 | ||||||
Teachers | 14 | 14 | 15 | 0.80 | 0.43–1.49 | 0.49 | ||||||
TRIB1 | 8 | rs4512391 | 38 | 41 | All | 26 | 25 | 27 | 0.95 | 0.87 | 0.64–1.20 | 0.40 |
Dentists | 27 | 28 | 27 | 1.17 | 0.66–2.04 | 0.58 | ||||||
Teachers | 25 | 22 | 26 | 0.75 | 0.44–1.31 | 0.32 | ||||||
DIO2 | 14 | rs225014 | 42 | 39 | All | 28 | 27 | 29 | 0.10 | 0.85 | 0.62–1.17 | 0.32 |
Dentists | 28 | 30 | 27 | 1.05 | 0.60–1.85 | 0.88 | ||||||
Teachers | 28 | 24 | 31 | 0.72 | 0.42–1.23 | 0.24 | ||||||
TGFB1 | 19 | rs1800470/rs1982073 | 44 | NA | All | 29 | 31 | 29 | 0.58 | 1.15 | 0.85–1.57 | 0.36 |
Dentists | 31 | 29 | 31 | 1.10 | 0.63–1.93 | 0.71 | ||||||
Teachers | 28 | 32 | 25 | 1.29 | 0.75–2.23 | 0.36 |
Logistic regression analysis with log-additive model in group “All”, and dominant model in groups “Dentists” and “Teachers”.
ORs and 95% CIs are adjusted for age, occupation and body mass index (BMI) in group “All” and for age and BMI in groups “Dentists” and “Teachers”.