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. 2014 May 13;9(5):e97417. doi: 10.1371/journal.pone.0097417

Table 2. Association of studied polymorphisms with ROA in the total material and by occupation.

Gene Chr SNP MAF (%) Group MAF (%) Our study HWE ROA
NCBI HapMap Total Case Control (p-value) OR 95% CI p-value
Replication analyses
A2BP1 16 rs716508 39 28 All 35 31 36 0.09 0.68 0.50–0.93 0.01
Dentists 35 33 36 0.69 0.39–1.23 0.19
Teachers 34 28 37 0.58 0.34–1.01 0.05
COG5 7 rs3757713 14 21 All 19 20 18 0.07 1.16 0.83–1.63 0.38
Dentists 19 23 18 1.60 0.90–2.86 0.09
Teachers 18 18 18 0.97 0.54–1.75 0.92
COG5 7 rs3815148 19 22 All 19 20 18 0.12 1.14 0.81–1.59 0.45
Dentists 19 24 18 1.51 0.84–2.71 0.11
Teachers 18 17 18 0.90 0.50–1.62 0.74
GDF5 20 rs143383 29 32 All 43 41 43 0.55 0.93 0.70–1.22 0.58
Dentists 43 40 44 0.80 0.44–1.43 0.49
Teachers 42 42 42 1.21 0.68–2.14 0.51
HFE 6 rs1799945 8 18 All 13 13 12 0.53 1.15 0.76–1.74 0.52
Dentists 12 10 12 0.86 0.43–1.74 0.68
Teachers 14 15 13 1.55 0.84–2.88 0.19
ESR1 6 rs2234693 44 41 All 40 39 41 0.60 0.94 0.71–1.24 0.67
Dentists 41 40 41 0.80 0.45–1.43 0.45
Teachers 40 39 40 1.08 0.62–1.89 0.82
ESR1 6 rs9340799 26 30 All 25 26 25 0.20 1.05 0.76–1.45 0.78
Dentists 27 26 27 0.83 0.47–1.45 0.51
Teachers 24 26 23 1.62 0.94–2.79 0.08
Exploratory analyses
PTGS2 1 rs4140564 4 8 All 7 6 7 0.35 0.90 0.50–1.61 0.72
Dentists 6 3 7 0.40 0.13–1.21 0.08
Teachers 8 9 7 1.44 0.69–3.02 0.33
PARD3B 2 rs1207421 13 9 All 10 11 9 1.00 1.04 0.66–1.64 0.87
Dentists 10 12 9 1.17 0.59–2.33 0.67
Teachers 10 10 9 0.90 0.45–1.82 0.80
DVWA 3 rs7639618 26 18 All 16 16 16 0.95 1.11 0.76–1.63 0.58
Dentists 18 19 17 1.52 0.84–2.76 0.16
Teachers 14 14 14 0.82 0.44–1.52 0.57
HLA 6 rs10947262 17 6 All 14 15 14 0.68 1.06 0.72–1.56 0.78
Dentists 15 16 14 1.10 0.59–2.05 0.82
Teachers 14 14 14 1.01 0.54–1.89 0.99
BCAP29 7 rs10953541 14 27 All 26 27 25 0.18 1.09 0.81–1.48 0.58
Dentists 27 29 26 1.43 0.81–2.51 0.18
Teachers 24 25 24 1.06 0.61–1.83 0.78
DUS4L 7 rs4730250 12 17 All 15 17 15 0.23 1.15 0.80–1.66 0.46
Dentists 16 20 14 1.63 0.89–2.97 0.10
Teachers 14 14 15 0.80 0.43–1.49 0.49
TRIB1 8 rs4512391 38 41 All 26 25 27 0.95 0.87 0.64–1.20 0.40
Dentists 27 28 27 1.17 0.66–2.04 0.58
Teachers 25 22 26 0.75 0.44–1.31 0.32
DIO2 14 rs225014 42 39 All 28 27 29 0.10 0.85 0.62–1.17 0.32
Dentists 28 30 27 1.05 0.60–1.85 0.88
Teachers 28 24 31 0.72 0.42–1.23 0.24
TGFB1 19 rs1800470/rs1982073 44 NA All 29 31 29 0.58 1.15 0.85–1.57 0.36
Dentists 31 29 31 1.10 0.63–1.93 0.71
Teachers 28 32 25 1.29 0.75–2.23 0.36

Logistic regression analysis with log-additive model in group “All”, and dominant model in groups “Dentists” and “Teachers”.

ORs and 95% CIs are adjusted for age, occupation and body mass index (BMI) in group “All” and for age and BMI in groups “Dentists” and “Teachers”.