Table 3. Association of studied polymorphisms with symptomatic DIP OA in the total material and by occupation.
| Gene | Chr | SNP | MAF (%) | Group | MAF (%)This study | HWE | Symptomatic DIP OA | |||||
| NCBI | HapMap | Total | Case | Control | (p-value) | OR | 95% CI | p-value | ||||
| Replication analyses | ||||||||||||
| A2BP1 | 16 | rs716508 | 39 | 28 | All | 35 | 35 | 35 | 0.09 | 0.94 | 0.58–1.52 | 0.80 |
| Dentists | 35 | 38 | 35 | 0.69 | 0.26–1.81 | 0.38 | ||||||
| Teachers | 34 | 33 | 34 | 1.06 | 0.47–2.38 | 0.94 | ||||||
| COG5 | 7 | rs3757713 | 14 | 21 | All | 19 | 24 | 18 | 0.07 | 1.46 | 0.90–2.37 | 0.13 |
| Dentists | 19 | 23 | 19 | 1.35 | 0.51–3.54 | 0.62 | ||||||
| Teachers | 18 | 24 | 17 | 1.81 | 0.80–4.12 | 0.16 | ||||||
| COG5 | 7 | rs3815148 | 19 | 22 | All | 19 | 25 | 18 | 0.12 | 1.35 | 0.83–2.19 | 0.24 |
| Dentists | 19 | 23 | 19 | 1.37 | 0.52–3.59 | 0.60 | ||||||
| Teachers | 18 | 26 | 17 | 1.41 | 0.61–3.23 | 0.42 | ||||||
| GDF5 | 20 | rs143383 | 29 | 32 | All | 43 | 39 | 43 | 0.55 | 0.83 | 0.54–1.29 | 0.41 |
| Dentists | 43 | 38 | 43 | 0.76 | 0.29–2.00 | 0.50 | ||||||
| Teachers | 42 | 40 | 43 | 0.74 | 0.32–1.69 | 0.50 | ||||||
| HFE | 6 | rs1799945 | 8 | 18 | All | 13 | 15 | 12 | 0.53 | 1.49 | 0.80–2.76 | 0.22 |
| Dentists | 12 | 18 | 11 | 2.29 | 0.83–6.29 | 0.11 | ||||||
| Teachers | 14 | 14 | 14 | 1.41 | 0.57–3.49 | 0.48 | ||||||
| ESR1 | 6 | rs2234693 | 44 | 41 | All | 40 | 45 | 40 | 0.60 | 1.27 | 0.83–1.94 | 0.28 |
| Dentists | 41 | 45 | 40 | 1.33 | 0.48–3.70 | 0.56 | ||||||
| Teachers | 40 | 45 | 39 | 1.47 | 0.62–3.46 | 0.38 | ||||||
| ESR1 | 6 | rs9340799 | 26 | 30 | All | 25 | 31 | 25 | 0.20 | 1.39 | 0.86–2.24 | 0.19 |
| Dentists | 27 | 23 | 27 | 0.50 | 0.19–1.33 | 0.15 | ||||||
| Teachers | 24 | 36 | 22 | 2.84 | 1.25–6.48 | 0.01 | ||||||
| Exploratory analyses | ||||||||||||
| PTGS2 | 1 | rs4140564 | 4 | 8 | All | 7 | 4 | 7 | 0.35 | 0.53 | 0.18–1.56 | 0.22 |
| Dentists | 6 | 0 | 6 | – | – | – | ||||||
| Teachers | 8 | 7 | 8 | 0.83 | 0.26–2.64 | 0.73 | ||||||
| PARD3B | 2 | rs1207421 | 13 | 9 | All | 10 | 10 | 10 | 1.00 | 0.91 | 0.45–1.87 | 0.80 |
| Dentists | 10 | 10 | 10 | 0.90 | 0.28–2.93 | 0.84 | ||||||
| Teachers | 10 | 10 | 10 | 0.79 | 0.27–2.25 | 0.68 | ||||||
| DVWA | 3 | rs7639618 | 26 | 18 | All | 16 | 14 | 16 | 0.95 | 0.93 | 0.50–1.71 | 0.81 |
| Dentists | 18 | 13 | 18 | 0.81 | 0.27–2.36 | 0.70 | ||||||
| Teachers | 14 | 16 | 14 | 1.02 | 0.42–2.52 | 0.97 | ||||||
| HLA | 6 | rs10947262 | 17 | 6 | All | 14 | 13 | 14 | 0.68 | 0.90 | 0.48–1.68 | 0.74 |
| Dentists | 15 | 20 | 14 | 1.78 | 0.67–4.71 | 0.25 | ||||||
| Teachers | 14 | 9 | 14 | 0.59 | 0.21–1.64 | 0.32 | ||||||
| BCAP29 | 7 | rs10953541 | 14 | 27 | All | 26 | 32 | 25 | 0.18 | 1.36 | 0.86–2.15 | 0.19 |
| Dentists | 27 | 28 | 27 | 1.07 | 0.42–2.77 | 0.99 | ||||||
| Teachers | 24 | 35 | 23 | 1.64 | 0.73–3.65 | 0.21 | ||||||
| DUS4L | 7 | rs4730250 | 12 | 17 | All | 15 | 20 | 15 | 0.23 | 1.44 | 0.84–2.45 | 0.19 |
| Dentists | 16 | 20 | 16 | 1.76 | 0.66–4.65 | 0.31 | ||||||
| Teachers | 14 | 21 | 14 | 1.49 | 0.63–3.50 | 0.34 | ||||||
| TRIB1 | 8 | rs4512391 | 38 | 41 | All | 26 | 20 | 27 | 0.95 | 0.67 | 0.39–1.15 | 0.14 |
| Dentists | 27 | 25 | 28 | 0.99 | 0.39–2.53 | 0.96 | ||||||
| Teachers | 25 | 17 | 26 | 0.53 | 0.22–1.23 | 0.13 | ||||||
| DIO2 | 14 | rs225014 | 42 | 39 | All | 28 | 31 | 28 | 0.10 | 1.13 | 0.69–1.85 | 0.63 |
| Dentists | 28 | 35 | 27 | 1.76 | 0.66–4.68 | 0.28 | ||||||
| Teachers | 28 | 28 | 29 | 0.92 | 0.41–2.04 | 0.79 | ||||||
| TGFB1 | 19 | rs1800470/rs1982073 | 44 | NA | All | 29 | 40 | 28 | 0.58 | 1.84 | 1.16–2.91 | 0.01 |
| Dentists | 31 | 40 | 30 | 1.57 | 0.60–4.09 | 0.36 | ||||||
| Teachers | 28 | 40 | 26 | 2.72 | 1.16–6.39 | 0.03 | ||||||
Logistic regression analysis with log-additive model in group “All”, and dominant model in groups “Dentists” and “Teachers”.
ORs and 95% CIs are adjusted for age, occupation and body mass index (BMI) in group “All” and for age and BMI in groups “Dentists” and “Teachers”.
NCBI-population is 1000 genomes.
HapMap population is CEU: Utah residents with Northern and Western European ancestry from the CEPH collection.