Table 4. Individual and joint effect of selected SNPs on ROA and symptomatic DIP OA.

			ROA				Symptomatic DIP OA
			N	OR	95% CI	p-value*	N	OR	95% CI	p-value*
COG5-BCAP29	COG5 rs3757713 C-allele carriage	BCAP29 rs10953541 T-allele carriage				0.034				0.54
	No	No	74/277	1.00			21/277	1.00
	Yes	No	11/27	2.57	1.08–6.10		3/27	2.20	0.57–6.40
	No	Yes	30/88	1.53	0.89–2.65		8/88	1.24	0.51–3.00
	Yes	Yes	45/149	1.24	0.78–1.97		17/149	1.62	0.80 –3.26
Carriage of COG5 C or BCAP29 T allele			86/264	1.48	1.07–2.06		28/264	1.55	0.93–2.58
HFE–ESR1	HFE rs179945 G–allele carriage	ESR1 rs9340799 C–allele carriage				0.19				0.096
	No	No	63/237	1.00			15/237	1.00
	Yes	No	21/60	1.60	0.84–3.03		9/60	3.01	1.19–7.58
	No	Yes	58/180	1.34	0.86–2.11		19/180	1.86	0.89–3.87
	Yes	Yes	18/65	1.16	0.61–2.21		6/65	1.77	0.63 –4.95
Carriage of HFE G or ESR1 C allele			97/305	1.35	0.98–1.86		34/305	2.12	1.28–3.50

*p-value for interaction; ORs and 95% CIs are adjusted for age, occupation and body mass index.