Table S2.
Degree of concordance among apoB, LDL-C, and non-HDL-C levels at baseline and study endpoint in the pooled treatment groups for the overall population and patient subgroups defined by baseline TG <2.26 and ≥2.26 mmol/L
| N | Concordance between apoB and LDL-C Weighted kappa (95% CI) |
N | Concordance between apoB and non-HDL-C Weighted kappa (95% CI) |
|
|---|---|---|---|---|
| Baseline (ie, drug-naïve patients) | ||||
| Pooled across treatment groups | ||||
| All patients | 1,233 | 0.44 (0.41–0.48) | 1,233 | 0.64 (0.61–0.66) |
| TG <2.26 mmol/L | 983 | 0.51 (0.47–0.54) | 983 | 0.62 (0.59–0.65) |
| TG ≥2.26 mmol/L | 250 | 0.50 (0.43–0.57) | 250 | 0.56 (0.50–0.63) |
| ERN/LRPT | ||||
| All patients | 155 | 0.37 (0.26–0.47) | 155 | 0.63 (0.55–0.70) |
| TG <2.26 mmol/L | 121 | 0.49 (0.38–0.59) | 121 | 0.58 (0.49–0.68) |
| TG ≥2.26 mmol/L | 34 | 0.33 (0.12–0.58) | 34 | 0.42 (0.21–0.62) |
| Pooled SIMVA | ||||
| All patients | 561 | 0.49 (0.44–0.53) | 561 | 0.65 (0.61–0.69) |
| TG <2.26 mmol/L | 444 | 0.55 (0.50–0.60) | 444 | 0.63 (0.58–0.67) |
| TG ≥2.26 mmol/L | 117 | 0.49 (0.38–0.60) | 117 | 0.53 (0.43–0.63) |
| Pooled ERN/LRPT + SIMVA | ||||
| All patients | 517 | 0.42 (0.37–0.47) | 517 | 0.64 (0.60–0.68) |
| TG <2.26 mmol/L | 418 | 0.48 (0.43–0.54) | 418 | 0.62 (0.56–0.67) |
| TG ≥2.26 mmol/L | 99 | 0.56 (0.46–0.66) | 99 | 0.66 (0.56–0.75) |
| Endpoint (ie, following randomized treatment) | ||||
| ERN/LRPT | ||||
| All patients | 160 | 0.66 (0.59–0.73) | 160 | 0.78 (0.73–0.84) |
| TG <2.26 mmol/L | 124 | 0.72 (0.65–0.79) | 124 | 0.81 (0.75–0.88) |
| TG ≥2.26 mmol/L | 36 | 0.50 (0.35–0.66) | 36 | 0.80 (0.69–0.91) |
| Pooled SIMVA | ||||
| All patients | 564 | 0.66 (0.63–0.70) | 564 | 0.81 (0.78–0.83) |
| TG <2.26 mmol/L | 447 | 0.69 (0.65–0.73) | 447 | 0.79 (0.75–0.82) |
| TG ≥2.26 mmol/L | 117 | 0.67 (0.59–0.74) | 117 | 0.77 (0.71–0.84) |
| Pooled ERN/LRPT + SIMVA | ||||
| All patients | 519 | 0.80 (0.77–0.83) | 519 | 0.85 (0.82–0.88) |
| TG <2.26 mmol/L | 419 | 0.78 (0.75–0.82) | 419 | 0.84 (0.81–0.87) |
| TG ≥2.26 mmol/L | 100 | 0.81 (0.74–0.88) | 100 | 0.87 (0.81–0.93) |
Notes: The k statistic, on a scale from 0 to 1, reflects the degree of agreement between two variables. The levels of agreement range from slight (0–0.20), fair (0.21–0.40), moderate (0.41–0.60), substantial (0.61–0.80), and almost perfect (0.81–1.00).
Abbreviations: apoB, apolipoprotein B; ERN, extended-release niacin; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; LRPT, laropiprant; SIMVA, simvastatin; TG, baseline triglyceride value.