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. 2014 May 7;9:2167–2178. doi: 10.2147/IJN.S60178

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© 2014 Ye et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Typical pictures of cellular apoptosis analyzed by flow cytometry.

Notes: HeLa cells were treated with different formulations (A–D) for 24 hours. The final concentration of imatinib in these formulations is 350 μM. (A) untreated control; (B) F-L-imatinib; (C) L-imatinib; (D) F-L-imatinib plus 1 mM of free folic acid.

Abbreviations: F-L-imatinib, folate receptor-targeted liposomal imatinib; L-imatinib, non-targeted liposomal imatinib; FITC-A, fluorescein isothiocyanate apoptosis; PI-A, propidium iodide apoptosis; Q, quadrant.