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. 2014 May 13;9(5):e97361. doi: 10.1371/journal.pone.0097361

Figure 2. TLR4 mutant (C3H/HeJ) and null (B10ScNJ) mice are insensitive to lipopolysaccharide (LPS)-induced mechanical hyperalgesia.

Figure 2

Mechanical thresholds in control (C3H/HeOuJ, B10ScSNJ) or TLR4 mutant/null mice were measured prior to and 24 h after LPS (1 mg/kg, i.p.) injection. No difference between baseline withdrawal thresholds was observed between genotypes. The number of paw withdrawals significantly increased in control mice 24 h post-LPS injection. No difference in mechanical sensitivity was observed between baseline and 24 h post-injection responses in TLR4 mutant mice. Data represent means for n = 10 per group. Statistical analyses were performed using a two-way ANOVA followed by Bonferroni post hoc test. The asterisk denotes a significant difference from baseline control response. ***p<0.001.