Table 1.

Medroxyprogesterone acetate pharmacokinetic parameters estimates by annualized percentage increase in body mass index

Pharmacokinetic Parameter Estimate	BMI gain ≥10% (n=11)	BMI gain <10% (n=29)	p-valuea
Cmaxb			0.145
Mean (SD)	2.61 (1.04)	3.23 (1.21)
Median	2.52	2.92
Min - Max	1.27 – 4.70	1.57 – 6.12
Cmax <2.88			0.049
n(%)	8 (72.7)	11 (37.9)
Elimination Rate Constantc,d			0.196
Mean (SD)	0.011 (0.006)	0.019 (0.017)
Median	0.009	0.016
Min - Max	0.003 – 0.021	0.002 – 0.076
Elimination Rate Constant <0.021			0.047
n(%)	8 (100.0)	18 (64.3)
Tmaxe			0.320
Mean (SD)	38.9 (28.81)	30.4 (21.88)
Median	28	27
Min - Max	7 – 87	6 – 87

^aUnadjusted Student’s t-test analyses p-value

^bMaximum serum medroxyprogesterone acetate concentration (ng/mL)

^cNatural logarithm medroxyprogesterone acetate elimination rate constant (ng/mL/day)

^dThree subjects with BMI gain ≥10% and one subject with BMI gain <10% had no post-peak concentration data and were missing from the elimination rate constant determination

^eTime to Cmax (days)