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Dose escalation schema and dose limiting toxicities (DLT) of High-dose (27Gy) I-131 tositumomab + fludarabine + ASCT
| Dose level | n | Fludarabine daily dose (mg/m2) | # of doses | Total dose (mg/m2) | # DLT |
|---|---|---|---|---|---|
| 0 | 7 | 10 | 5 | 50 | 0 |
| 1 | 5 | 15 | 5 | 75 | 0 |
| 2 | 5 | 20 | 5 | 100 | 0 |
| 3 | 5 | 25 | 5 | 125 | 0 |
| 4 | 6 | 30 | 5 | 150 | 0 |
| 5 | 5 | 30 | 6 | 180 | 0 |
| 6 | 3 | 30 | 7 | 210 | 0 |
