. Author manuscript; available in PMC: 2015 Jun 1.

Published in final edited form as: J Neuroimmune Pharmacol. 2014 Feb 25;9(3):354–368. doi: 10.1007/s11481-014-9524-6

Table 1.

Effects of acute in vitro application of 40 nM Tat and chronic in vivo exposure of cocaine on the membrane properties of rat mPFC pyramidal neurons that showed Tat-induced increases in spiking

	SAL-BlCtr	SAL-Tat	COC-BlCtr	COC-Tat
No. Neurons (No. Rats)	10 (10)	10 (10)	11 (5)	11 (5)
RMP (mV)	−67.8±1.3	−65.5±1.5^**	−67.0±1.6	−64.9±1.6⁺
R_in (MΩ)	192±26	236±24^*	206±17	264±28⁺⁺
Rheobase (nA)	0.11±0.01	0.07±0.01^**	0.08±0.01^*	0.06±0.01⁺
Threshold (mV)	−42.3±1.3	−42.5±1.3	−41.5±1.0	−38.4±2.2
½ Peak Duration (ms)	2.1±0.2	2.1±0.2	1.7±0.2	2.5±0.5⁺⁺
Amplitude (mV)	90.3±5.0	83.2±5.5^*	74.6±3.9^*	59.1±2.7⁺⁺,^##
AHP (mV)	8.5±1.5	7.9±1.4	12.4±1.3	8.6±0.8

Two-way rmANOVA:

RMP: acute Tat, F_(1,19)=19.893, p<0.001; chronic cocaine, F_(1,19)=0.042, p=0.840; Interaction, F_(1,19)=0.359, p=0.556

R_in: acute Tat, F_(1,19)=16.946, p<0.001; chronic cocaine, F_(1,19)=0.419, p=0.525; Interaction, F_(1,19)=0.236, p=0.633

Rheobase: acute Tat, F_(1,19)=38.214, p<0.001; chronic cocaine, F_(1,19)=1.418, p=0.248; Interaction, F_(1,19)=10.933, p=0.004

Threshold: acute Tat, F_(1,19)=1.195, p=0.288; chronic cocaine, F_(1,19)=2.099, p=0.164; Interaction, F_(1,19)=1.424, p=0.247

½ peak duration: acute Tat, F_(1,19)=5.670, p=0.028; chronic cocaine, F_(1,19)=0.001, p=0.984; Interaction, F_(1,19)=5.384, p=0.032

AP amplitude: acute Tat, F_(1,19)=10.350, p=0.005; chronic cocaine, F_(1,19)=12.500, p=0.002; Interaction, F_(1,19)=7.665, p=0.014

AHP: acute Tat, F_(1,19)=1.570, p=0.225; chronic cocaine, F_(1,19)=0.640, p=0.434; Interaction, F_(1,19)=0.997, p=0.331

post hoc Newman-Keuls:

p<0.05

^**

p<0.01; vs. SAL-BlCtr

⁺

p<0.05

⁺⁺

p<0.01; vs.COC-BlCtr

^##

p<0.01; vs. SAL-Tat