Fig. 3. Aprotinin Inhibits Apoptosis via Mitochondrial Pathway and 250KIU/ml is an Optimal Dose for Protection.

(a,b) Caspase 3/7 and 9 activities after 24hrs SD in primary cortical neuron culture. (c-e) Images after 24hrs SD in a neuron culture without Aprotinin. (f) Percentage of caspase3+ cells at 24hrs after SD with Aprotinin at the concentration of 0, 100, 250, 500, and 1000KIU/ml. *p < 0.05, **p < 0.01, ***p < 0.001 vs. Aprotinin 0KIU/ml by ANOVA with Bonferroni comparisons. Data are shown as mean ± SEM (n = 6-8).