Using the ancestry reference panel comprising the populations depicted in (A), LAMP-LD and MULTIMIX unanimously estimate a European ancestry of E280A in (B) for the haplotypes containing E280A (E280+). Continental ancestry estimation is also shown for haplotypes spanning the region that do not contain the mutation (E280A−). Similarly, using the reference ancestry panels depicted (C), both algorithms strongly support a Western European origin for haplotypes bearing E280A (D). Abbreviations: CEU, Utah Residents (CEPH) with Northern and Western European ancestry. FIN, Finnish in Finland. GBR, British in England and Scotland. HGDP, Human Genome Diversity Project. IBS, Iberian population in Spain. TSI, Toscani in Italia. YRI, Yoruba in Ibadan, Nigeria.