Table 1. Rapamycin attenuation of age-related pathologies in model systems.

Data from studies in yeast, invertebrates (worms, flies), and various mouse strains mice, as well as from a few human clinical trials suggest that, in addition to extending life span, rapamycin can positively impact multiple age-related pathologies, as would be predicted for a direct modulator of aging rates.

Age-related disorder	Model system
Cardiac dysfunction	Invertebrate (Drosophila melanogaster), Murine (multiple mouse strains)
Macular degeneration	Murine, Human clinical trial
Cancer	Murine, Human clinical trial
Stem cell decline	Invertebrate, Murine
Cognitive decline	Murine
Neurodegeneration	Invertebrate (Drosophila melanogaster, Caenorhabditis elegans), Murine
Immune decline	Murine
Renal dysfunction	Murine