Table 5.
Association of various risk factors with herpes zoster, stratified by age
| Key risk factors of interest | Adjusted odds ratio (99% CI)* | P value † | |||
|---|---|---|---|---|---|
| <50 years | 50-59 years | 60-69 years | ≥70 years | ||
| Rheumatoid arthritis | 1.69 (1.38 to 2.06) | 1.45 (0.93 to 2.28) | 1.49 (0.97 to 2.29) | 1.41 (0.93 to 2.15) | 0.203 |
| Systemic lupus erythematosus | 3.04 (2.14 to 4.31) | 1.98 (0.86 to 4.58) | 1.23 (0.52 to 2.89) | 1.29 (0.56 to 2.93) | <0.001 |
| Inflammatory bowel disease | 1.73 (1.47 to 2.03) | 1.40 (0.95 to 2.07) | 1.30 (0.88 to 1.90) | 1.18 (0.81 to 1.70) | <0.001 |
| Chronic obstructive pulmonary disease | 1.11 (0.80 to 1.54) | 1.29 (0.65 to 2.53) | 1.37 (0.71 to 2.66) | 1.30 (0.68 to 2.51) | 0.228 |
| Asthma | 1.24 (1.17 to 1.32) | 1.19 (1.02 to 1.39) | 1.22 (1.05 to 1.42) | 1.18 (1.02 to 1.37) | 0.465 |
| Chronic kidney disease | 1.63 (1.37 to 1.95) | 1.26 (0.85 to 1.87) | 1.14 (0.78 to 1.65) | 1.10 (0.77 to 1.57) | <0.001 |
| Depression | 1.24 (1.16 to 1.33) | 1.12 (0.94 to 1.33) | 1.08 (0.90 to 1.30) | 1.10 (0.93 to 1.30) | 0.002 |
| Diabetes | 1.28 (1.15 to 1.43) | 1.11 (0.87 to 1.42) | 1.01 (0.80 to 1.28) | 0.97 (0.77 to 1.22) | <0.001 |
| Diabetes type: | |||||
| Type 1 | 1.51 (1.22 to 1.88) | 1.16 (0.62 to 2.18) | 0.98 (0.46 to 2.08) | 0.62 (0.23 to 1.65) | <0.001 |
| Type 2 | 1.22 (1.05 to 1.42) | 1.09 (0.79 to 1.52) | 1.02 (0.74 to 1.40) | 0.97 (0.71 to 1.32) | |
| Unknown | 1.20 (0.95 to 1.50) | 1.30 (0.71 to 2.36) | 1.02 (0.57 to 1.81) | 1.07 (0.62 to 1.82) | |
*Adjusted for HIV, leukaemia, lymphoma, myeloma, haematopoietic stem cell transplantation, other unspecified cellular immune deficiencies, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, chronic obstructive pulmonary disease, asthma, chronic kidney disease, depression, diabetes, smoking, and alcohol.
†P value for interaction.