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. 2013 Jun 26;33(26):10729–10740. doi: 10.1523/JNEUROSCI.1501-13.2013

Figure 2.

Figure 2.

Characterization of PAK, membrane cofilin, and drebrin impairments in homozygous 3xTg-AD mice according to age. A, Soluble PAK1/2/3 was decreased in 12- and 20-month-old 3xTg-AD mice compared with NonTg mice of the same age. No statistical differences were found between the two genotypes in young animals (4 months). B, When comparing both genotypes at different ages, we observed no alteration of soluble phospho-PAK in 3xTg-AD mice at 4, 12, or 20 months. C, Loss of soluble PAK1/2/3 was observed in both isoforms 1 and 3 at all ages. Despite an age effect for drebrin level, we did not found any change of membrane cofilin (D) or drebrin (E) levels in 3xTg-AD compared with NonTg mice. Values are expressed as mean ± SEM. Statistical comparisons were performed using a one-way ANOVA followed by a Tukey-Kramer post hoc test (age comparison, A–C) and an unpaired t test (D,E). *p < 0.5, **p < 0.01, ***p < 0.001.