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. 2014 May 14;34(20):6910–6923. doi: 10.1523/JNEUROSCI.5441-13.2014

Figure 4.

Figure 4.

The Opt allele rescues elevated hippocampal RyR protein levels in M146V mice. A, Western blot analyses of hippocampal lysates from 5-week-old animals using a pan-RyR antibody (n = 6 mice each) or antibodies specific to RyR2 (n = 4 mice each) or RyR3 (n = 5 mice each) and heat-shock protein 90 as a loading control. Unpaired two-tailed t test, *p ≤ 0.05, **p ≤ 0.005. Error bars show mean and SEM. B, Immunofluorescence in brain slices from 5-week-old animals using an antibody specific to RyR2. Hippocampal region CA1 is shown.