Table 2.
Relation between the positivity of celiac disease specific antibodies and clinical presentation of Crohn’s disease
| tTG | DGP | ||||||
|---|---|---|---|---|---|---|---|
| Number of patients | Positive (n = 12) |
Negative (n = 50) |
p-value* | Positive (n = 12) |
Negative (n = 50) |
p-value* | |
| Median age, year (range) | 37.5 (23–52) | 38.8 (18–75) | 0.691 | 38.2 (24–64) | 38.6 (18–75) | 0.940 | |
| Mean disease duration (year) | 9.5 | 10.1 | 0.374 | 10.2 | 9.6 | 0.813 | |
| Localization of the disease (n) | 0.144 | 0.633 | |||||
| UGI | 2 | 4 | 0.312 | 3 | 3 | 0.074 | |
| Jejunum/ileum | 11 | 37 | 0.131 | 10 | 38 | 0.370 | |
| Colon | 10 | 37 | 0.320 | 8 | 34 | 0.608 | |
| Clinical type of disease (n) | 0.467 | 0.482 | |||||
| Penetrating | 5 | 10 | 0.202 | 5 | 10 | 0.202 | |
| Structuring | 5 | 22 | 0.615 | 4 | 23 | 0.362 | |
| Inflammatory | 5 | 23 | 0.872 | 4 | 24 | 0.872 | |
| Stoma (n) | 4 | 8 | 0.178 | 4 | 9 | 0.248 | |
| Medication (n) | 0.482 | 0.979 | |||||
| Immunomodulators** | 7 | 24 | 0.329 | 7 | 24 | 0.329 | |
| Corticosteroid | 1 | 8 | 0.461 | 2 | 9 | 0.663 | |
| Elemental diet | 9 | 32 | 0.299 | 7 | 36 | 0.856 | |
| Harvey-Bradshaw index (HBI) | 5.61 ± 2.69 | 1.31 ± 0.80 | <0.01 | 5.18 ± 2.76 | 1.25 ± 0.20 | <0.01 | |
| Laboratory values | |||||||
| Albumin (g/dl) | 3.83 ± 0.84 | 4.25 ± 0.36 | 0.312 | 4.10 ± 0.65 | 4.03 ± 0.52 | 0.695 | |
| Total cholesterol (mg/dl) | 138.7 ± 43.0 | 152.7 ± 45.0 | 0.397 | 143.2 ± 43.7 | 151.2 ± 45.1 | 0.651 | |
| Hemoglobin (g/dl) | 12.9 ± 2.09 | 12.7 ± 2.04 | 0.849 | 12.7 ± 2.55 | 12.9 ± 1.94 | 0.937 | |
| CRP (mg/dl) | 0.83 ± 1.69 | 0.86 ± 2.38 | 0.829 | 0.78 ± 1.65 | 0.54 ± 0.57 | 0.617 | |
tTG serum tissue trans glutaminase (IgA), DGP serum deamidated gliadin peptide (IgA), UGI upper gastrointestinal tract, proximal to the jejunum, CRP C-reactive protein. The data are presented as the mean values with standard deviations
* Statistical comparison between sero-positive and sero-negative
** Azathioprine, 6-mercaptopurine, and anti-TNF agents