Table 4.
Effect of beta-hydroxy-beta-methylbutyrate free acid (HMB-FA) supplementation on serum creatine kinase (CK), cortisol, and perceived recovery score (PRS) in participants performing a 12-week resistance-training regimen
| Week of study | p valuea | ||||
|---|---|---|---|---|---|
| 0 | 4 | 8 | 12 | ||
| Creatine kinase (IU/l) | |||||
| Placebo | 146 ± 62.3 | 388 ± 62.3 | 261 ± 62.3 | 195 ± 62.3 | |
| HMB-FA | 154 ± 62.3 | 275 ± 62.3# | 251 ± 62.3 | 142 ± 62.3 | 0.01 |
| Cortisol (μg/dl) | |||||
| Placebo | 20.3 ± 2.6 | 19.3 ± 2.6 | 19.9 ± 2.6 | 21.2 ± 2.6 | |
| HMB-FA | 21.0 ± 2.6 | 20.3 ± 2.6 | 18.2 ± 2.6 | 16.9 ± 2.6# | 0.004 |
| PRSb | |||||
| Placebo | 9.1 ± 0.8 | 7.1 ± 0.8 | 7.7 ± 0.8 | 7.6 ± 0.8 | |
| HMB-FA | 9.1 ± 0.8 | 7.6 ± 0.8 | 8.5 ± 0.8# | 9.5 ± 0.8# | 0.003 |
Adjusted least square mean ± SD for n = 11 HMB-FA (3 g HMB-FA/d in three 1 g doses) and n = 9 placebo-supplemented participants
aProbability of treatment by time difference between the placebo and the HMB-FA treatments over the 12-week study. The mixed model in SAS was used with the main effects of treatment, week and treatment by week, with the value for week 0 used as a covariate
bPerceived recovery score is rated on the participants feeling of recovery from the last workout on a scale of 0–10
#Significantly different than corresponding placebo, t test (p < 0.05)