Table 1.

Hepcidin levels, iron and hematological phenotype in the available murine models of Tfr2 inactivation.

Mouse model	Hepcidin expression	Iron phenotype	Hematological phenotype		Reference
			RBC	Hb
Tfr2Y245X/Y245X	Reduced*	Iron overload	n.a	Normal	Fleming et al. (2002), Kawabata et al. (2005)
Tfr2-/-	Reduced*	Iron overload	Normal	High	Roetto et al. (2010), Wallace et al. (2005)
Tfr2LCKO	Reduced*	Severe iron overload	Normal	Normal	Roetto et al. (2010), Wallace et al. (2007)
Tfr2KI	Normal	Moderate iron overload (old mice)	Low	Low	Roetto et al. (2010)
			(only in young mice)
Tfr2-/-Hfe-/-	Low	Severe iron overload	n.a	n.a.	Wallace et al. (2009)
Tfr2Y245X/Y245XHfe-/-	Very low	Severe iron overload	n.a	n.a.	Corradini et al. (2011)
Tfr2Y245X/Y245XTmprss6msk/msk	High	Iron deficiency	High	Low	Lee et al. (2012)
Tfr2-/-Tmprss6-/-	High	Iron deficiency	High	Low	Nai et al. (2014)
Tfr2LCKOTmprss6-/-	Very high	Iron deficiency	High	Low	Nai et al. (2014)

RBC, red blood cells; Hb, hemoglobin.

^*Reduced compared to the level of iron-loaded mice; n.a = not available.