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. 2014 May 7;8:168. doi: 10.3389/fnbeh.2014.00168

Figure 2.

Figure 2

Deficits in the recall of fear extinction for context in the offspring of rats treated with polyI:C during pregnancy (saline, n = 14 from 7 dams; polyI:C, n = 10 from 5 dams). (A) Schematic of experimental design. During Fear Conditioning rats received 5 tone-shock pairings. One day later (Extinction acquisition), the fear cue was presented 20 times without shock in the training context. This was repeated the next day (Extinction recall). (B) Cued Freezing. Percent time freezing during blocks of 2 fear cues is shown for each phase of the experiment. No differences between groups were detected. (C) Contextual Freezing. Percent time freezing during the 180 s interval after blocks of 2 trials is shown for each phase of the experiment. Also included is the percent time freezing during the 180 s prior to the first cue presentation (baseline, BL). The offspring of polyI:C-treated rats showed higher contextual freezing during Extinction #2 during BL (*p < 0.05) and the intervals between the cue presentations (#p < 0.05).