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. 2014 May 7;8:153. doi: 10.3389/fnbeh.2014.00153

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Copyright © 2014 Marotta, Fenu, Scheggi, Vinci, Rosas, Falqui, Gambarana, De Montis and Acquas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of CTA expression on subcellular p-ERK distribution. (A): histograms showing p-ERK density inside nucleus and cytoplasm of neuron cell bodies belonging to AcbSh of lithium conditioned (CS⁺-US⁺) and control rats (CS⁺-US⁻) (Expr2); histograms represent pooled data obtained from rats sacrificed 3 (group A) and 23 (group B) min after the beginning of testing. Values are average + s.e.m. ^**Indicate significant differences (p < 0.01) in average density gold particles between US⁻ and US⁺ rats (One-Way ANOVA). (B): histograms showing the percentage of p-ERK-positive synaptic profiles out of the total number of synapses that were randomly sampled inside the AcbSh of lithium conditioned (CS⁺-US⁺) and control rats (CS⁺-US⁻) (Expr2); histograms represent pooled data obtained from rats sacrificed 3 (group A) and 23 (group B) min after the beginning of testing. Values are average + s.e.m. ^**Indicate significant differences (p < 0.01) in number of pERK labeled excitatory profiles (%) between US⁻ and US⁺ rats (One-Way ANOVA). (C,D): sub-synaptic distribution of p-ERK in dendritic spine compartments (core, shell, and PSD). (C): histograms showing the density of gold particles (number of gold particles/μm²) observed in each sub-synaptic compartment. (D): Representative TEM micrograph of a dendritic spine subdivided in three compartments: core, shell, and PSD. Arrowhead points to gold particles. Scale bar is 500 nm.