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. 2014 May 7;6:81. doi: 10.3389/fnagi.2014.00081

Figure 4.

Figure 4

LOU rats exhibit a low anxiety phenotype in the elevated plus maze task and LTCR reduces anxious behavior in old SD rats. (A) LOU rats traveled over 100 cm on the EPM open arms, revealing high explorative behaviors and low anxiety. (B) No significant difference was observed between aging male and female LOU rats. (C) Locomotor activity increased with age for the LOU rats to become significantly different in O/O rats. (D) This effect is specific to females. (E) OAL SD rats did not explore the EPM open arms, indicating stress-related anxious behaviors. LTCR enhanced explorative behaviors in old SD rats. (F) OCR SD rats traveled a higher total distance in the EPM arena compared to YAL rats, suggesting lower anxiety and higher explorative behavior in a bright environment. Representative paths are shown (open arms in gray). Values are means ± s.e.m.; n SD = 5–11/age group; n LOU = 12–15/age group. Significance of changes for distances traveled in the open arms and total distances were determined by One-Way ANOVA followed by Bonferroni post-test, *p < 0.05, ***p < 0.001; YAL vs. OCR: ##p < 0.01; OAL vs. OCR: +p < 0.05.