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Pile up of the C-terminus amino acid sequences of L-ferritin and the mutants causing neuroferritinopathy. All mutations, localized in the exon 4 of FTL, are nucleotide insertions that cause large alterations of the C-terminal region of the subunit. This peptide portion forms the E-helix region, which is involved in the formation of the hydrophobic channel of the ferritin shell. Position of the A96T mutation is indicated by a blue arrow along the C-helix.
