Table 2.

Gap junctional expression changes associated with human epilepsy.

Gene	Epileptic condition	Brain region	Expression change		References
			mRNA	Protein
Cx32	Temporal lobe epilepsy (TLE)	Neocortex	Increased		Naus et al., 1991; Jin and Chen, 2011
		Hippocampus	Decreased		Collignon et al., 2006
Cx36	TLE	Hippocampus	Unchanged
Cx43	Intractable seizure			Increased	Naus et al., 1991
	Complex partial seizure disorder		No significant change		Elisevich et al., 1997
	TLE	Hippocampus Cortex	Increased		Jin and Chen, 2011
	Epilepsy associated brain tumors	Perilesional Cortex		Low-grade gliomas showed Increased expression and different isoforms (like controls) but most high-grade gliomas had only one isoform (non-phosphorylated)	Aronica et al., 2001
	Generalized seizure in the progression of mesial temporal lobe epilepsy	Hippocampus	Increased		Fonseca et al., 2002
Panx1	TLE	Cortex		Increased	Jiang et al., 2013
Panx2				No change
Panx1+Panx2				Only in layers II and III in the control but present in all layers in TLE patients