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Calcium response to fluid flow in cell cultures. (a) The induction of fluid flow causes a rise in calcium in cells (pseudocolored). (b) In transgenic cell lines with knocked-out Pkd1 or Tg737, both of which are ciliary proteins, calcium response is lost. The cells were incubated with fluorescent calcium dyes. Blue represents a low level; red denotes a higher level of calcium. Taken and adapted from [7].
