Fig. 4. Effect of CRT0066101 on in vivo tumor growth.
Athymic nude mice bearing HCT116 tumor xenografts were administered daily vehicle control (dextrose) or CRT0066101 at 40, 80, and 120 mg/kg orally for 3 weeks (5 mice per group). Tumor volume (A) and body weight (B) were measured 3 times per week. (C) Mouse and excised tumor images after treatment with CRT0066101. (D) Protein expression in xenografts was determined after 3 weeks of CRT0066101 treatment. Tumors were harvested 2 hours after the last dose.