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. Author manuscript; available in PMC: 2014 May 14.
Published in final edited form as: Biochem J. 2014 Feb 15;458(1):95–107. doi: 10.1042/BJ20130685

Figure 4. Proteasome inhibitors MG-132 and Lac suppress hCAR1 constitutive activity.

Figure 4

COS-1 cells were transfected with hCAR1 expression vector along with the 3.1-RXRα expression vector, pRL-CMV normalization vector and CYP2B6-PBREM/XREM reporter. Transfected cells were treated with either vehicle (0.1% DMSO), CITCO (2 µM), MG-132 (MG) (0.1, 1 and 10 µM) or Lac (0.5, 1 and 5 µM). After 24 h treatments, luciferase activities were determined and expressed relative to vehicle control. Data are the means ± S.D. (n = 3). Significantly different from DMSO and CITCO (*), P < 0.05.