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. Author manuscript; available in PMC: 2014 May 14.
Published in final edited form as: Biochem J. 2014 Feb 15;458(1):95–107. doi: 10.1042/BJ20130685

Figure 9. The proteasome subunit SUG1 suppresses the constitutive and ligand-mediated activity of hCAR1.

Figure 9

COS-1 cells were co-transfected with hCAR1 expression vector and various amounts of pCMV6-SUG1 expression vector, along with the CYP2B6-PBREM/XREM reporter. Transfected cells were treated for 24 h with vehicle control (0.1 % DMSO) or 10 µM Andro in the presence and absence of 2 µM CITCO. After treatment, luciferase activity was determined. Data are the means ± S.D. (n = 3). Significantly different from hCAR1 activity in control cells (no SUG1) treated with DMSO or Andro plus CITCO (**), P < 0.05.