High‐resolution interaction map of the human Hpo core kinase cassette and the STRIPAK complex. Bait proteins are indicated as hexagons, prey proteins as circles. Node color corresponds to the modules defined in Fig
2. Solid lines are interactions found by AP‐MS in this study, dotted, red lines are obtained from public protein interaction databases. The Hpo kinase homologs MST1 and MST2 interact with SAV1 and all RASF proteins in the SARAH module. The assembly of MOB1A/B and LATS1 forms the downstream kinase cascade of Hpo and associates with the LATS1 substrate YAP1. MST1 and RASF3 interact with the STRIPAK complexes.