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. 2014 May 13;460(Pt 2):165–175. doi: 10.1042/BJ20131639

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© 2014 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) Schematic representation of the domain structure of TRPM6 depicting the missense mutations identified in patients suffering from HSH. (B) Immunoprecipitated FLAG-tagged wild-type and kinase-inactive (KI) TRPM6 and indicated mutants were subjected to a kinase assay using MBP as substrate. Proteins were separated by SDS/PAGE, stained with Coomassie Blue (top and middle panels) and MBP phosphorylation was detected by autoradiography (bottom panel). Molecular masses are indicated in kDa.