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. Author manuscript; available in PMC: 2015 May 14.
Published in final edited form as: J Ethnopharmacol. 2014 Mar 22;153(3):732–736. doi: 10.1016/j.jep.2014.03.037

Table 1.

Pharmacokinetic parameters for artemisinin after oral gavage of healthy or P. chabaudi-infected mice with pACT.

Dose per animal
(mg AN kg−1)		 Disease
status		 # of subj. Artemisinin
Cmax
(mg L−1)		 Tmax
(min)		 T½
(min)		 AUC
(mg·min L−1)
100 healthy 4–6 4.33 ± 0.40 60 51.6 ± 299.5a
100 infected 5 ≥ 6.64 ≥ 120 nd 435.6b

Animals were fed A. annua dried leaves (pACT) to deliver 100 mg AN kg−1; average body weight was 23 g; nd, not determined.

Letters a, b after AUC values indicate statistical difference at p≤0.05; values are ± SE.