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. 2014 Apr 22;111(18):E1823–E1832. doi: 10.1073/pnas.1401182111

Fig. 4.

Fig. 4.

Applications of FM-HCR to assessment interindividual DRC differences and identification of DNA repair inhibitors and enhancers. (A) FM-HCR analysis of repair capacity in five pathways for 27 cell lines. Cells were transfected with plasmid combination 3 or 6. (B) Correlation between MGMT transcript levels measured by TaqMan qPCR and %R.E. (log transformed) from the MGMT HCR. (C) FM-HCR measurements of NER inhibition. (D) FM-HCR measurements of compound 401 inhibition of DRC in four pathways. For all experiments, cells were assayed by flow cytometry 18 h after transfection. See also Fig. S4.