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Cartoon of the secondary structure of the three families of the SAM clan of riboswitches. The phylogenetically conserved SAM-binding core shared by all members of the clan is highlighted in yellow, and the two types of peripheral subdomains, the P4/PK-1/P2 (called the PK-1 subdomain) and P5/PK-2 (called the PK-2 subdomain), are highlighted in green and cyan, respectively.
