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In vivo lacZ reporter assay. Gray boxes represent the wild-type binding core of SAM-I/IV, and hashed boxes represent the U47A binding knockout. PK-2 destabilizing mutants are denoted as ∆U (∆U92), ∆UG (∆U92,G93), ∆UGU (∆U92-U94), and ∆UGUC (∆U92-C95). ∆L3 is a mutant that changes the sequence of L3 to a UUCG tetraloop. Fold repression is shown below the graph. All errors are the SD of three individual biological replicates.
