Fig. 4.
Myeloid cell mPGES-1 deletion coincides with a reduced proinflammatory response and reduced oxidative stress during atherogenesis. (A) Real-time RT-PCR analysis of CD68, iNOS, TNFα, and MCP-1 expression in thoracic aortas from mice treated with HFD for 3 mo (n = 4, *P < 0.05). (B) Real-time RT-PCR analysis of NADPH oxidase subunits expression in thoracic aortas from mice treated with HFD for 3 mo (n = 4, *P < 0.05, **P < 0.01, ***P < 0.01). (C) Urinary 8,12-iso-iPF2α-VI in mice treated with a HFD for 3 mo (n = 12–13, *P < 0.05).