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. Author manuscript; available in PMC: 2015 Apr 9.
Published in final edited form as: Cell Host Microbe. 2014 Apr 9;15(4):413–423. doi: 10.1016/j.chom.2014.03.006

Figure 1.

Figure 1

PSA-stimulated IL-10 secretion by CD4+ T cells in splenic DC–CD4+ T cell co-culture is dependent on DCs. (A) IL-10 levels in culture supernatants (as measured by ELISA) are significantly higher in wells with PSA than in wells without PSA and suggest DC dependence of IL-10 secretion by CD4+ T-cells. Data represent the average of 4 independent experiments analyzed by Student's t-test. ***p<0.001; n.d., not detected; ns, not significant. (B) In co-cultures with IL-10−/− CD4+ T cells and WT DCs but not with WT CD4+ T cells and IL-10−/− DCs, essentially no IL-10 is produced; thus the major source of IL-10 in these co-cultures is CD4+ T cells. n.d., not detected.