Table 3.
Biological parameters of patients with BKV replication within bone marrow.
| Patient number | Time to cytopenia (months) | Hemoglobin level (g/dL) | PMN count (/mm3) | Platelet count (/mm3) | Lymphocyte count (/mm3) | CD4-positive cell count (/mm3) | CD8-positive cell count (/mm3) | CD19-positive cell count (/mm3) | Gamma globulins (g/dL) | eGFR* (mL/min) | Viruses in bone marrow (log10copies/mL) | Viruses in blood (log10copies/mL) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 4.5 | 12.9 | 713 | 231,000 | 700 | 575 | 297 | 58 | 6.2 | 54 | BKV (3.24) | None |
| 2 | 20 | 11.8 | 800 | 93,000 | 373 | 125 | 220 | 35 | 4.8 | 19 | BKV (3.01) | BKV (3) |
| 3 | 25 | 16.5 | 990 | 140,000 | 450 | 365 | 390 | 51 | 7.8 | 21 | BKV (3.01)-EBV | EBV |
| 4 | 12 | 9.4 | 678 | 187,000 | 155 | 34 | 27 | 13 | 4.5 | 17 | BKV (3.2) | BKV (2.8) |
| 5 | 12 | 13.1 | 430 | 249,000 | 500 | 280 | 223 | 100 | 5.7 | 19 | BKV (3.02) | BKV (5) |
| 6 | 15 | 10.7 | 100 | 65,000 | 1000 | 884 | 790 | 0 | 5 | 12 | BKV (2.74) | BKV (2.8) |
| 7 | 46.5 | 10.8 | 50 | 115,000 | 730 | — | — | 0 | 6 | 15 | BKV (2.94) | None |
| 8 | 6.5 | 13.5 | 726 | 99,000 | 700 | 297 | 174 | 91 | — | 32 | BKV (3.1) | BKV (2.8) |
*The glomerular filtration rate was calculated using the Modification of the Diet in Renal Disease (MDRD) equation.
PMN: polymorphonuclear leukocytes; eGFR: estimated glomerular-filtration rate.