Table 1.
Demographic, clinical, and biochemical parameters of the study subjects of T2D and Ctrl.
| T2D n = 71 |
Ctrl n = 52 |
P | |
|---|---|---|---|
| Age (yrs) | 54.55 ± 8.37 | 51.27 ± 7.66 | 0.028 |
| Male [(n (%)] | 40 (56.34) | 30 (57.69) | 0.881 |
| Current smokers [(n (%)] | 21 (29.58) | 14 (26.92) | 0.784 |
| Current drinkers [(n (%)] | 13 (18.31) | 8 (15.38) | 0.670 |
| Use of aspirin [(n (%)] | 8 (11.27) | 4 (7.69) | 0.509 |
| Use of statin [(n (%)] | 7 (9.86) | 4 (7.69) | 0.677 |
| Use of antihypertensive drugs[(n (%)] | 6 (8.45) | 5 (9.62) | 0.823 |
| HADS-D score (point)* | 8 (6, 9) | 8 (6, 9) | 0.200 |
| HADS-D ≥ 10 [(n (%)] | 17 (23.9) | 5 (9.6) | 0.041 |
| BMI (kg/m2) | 25.21 ± 2.19 | 23.86 ± 1.47 | 0.000 |
| Waist circumstance (cm) | 87.5 (81.8, 94.0) | 82.0 (78.0, 86.0) | 0.000 |
| WHR | 0.84 (0.77, 0.89) | 0.80 (0.74, 0.84) | 0.000 |
| Systolic blood pressure (mmHg) | 132 (120, 141) | 127 (123, 130) | 0.040 |
| Diastolic blood pressure (mmHg) | 81 (75, 88) | 74 (68, 80) | 0.000 |
| HbA1c (%) | 8.29 (7.58, 8.90) | 5.10 (4.80, 5.40) | 0.000 |
| FPG (mmol/L) | 8.72 ± 1.39 | 5.44 ± 0.35 | 0.000 |
| FIN (mIU/L) | 11.44 (6.99, 13.29) | 12.22 (7.8, 14.32) | 0.520 |
| HOMA-IR | 4.51 (2.73, 5.54) | 2.93 (2.00, 3.29) | 0.000 |
| Total cholesterol (mmol/L) | 4.69 ± 0.90 | 4.05 ± 0.54 | 0.000 |
| Triglyceride (mmol/L) | 1.86 (1.12, 2.31) | 1.20 (0.86, 1.32) | 0.000 |
| HDL-cholesterol (mmol/L) | 1.15 ± 0.24 | 1.22 ± 0.27 | 0.020 |
| LDL-cholesterol (mmol/L) | 2.47 ± 0.78 | 2.21 ± 0.67 | 0.050 |
| 8-OHdG (ng/mL) | 1.75 ± 0.51 | 1.16 ± 0.31 | 0.000 |
| T/S ratio | 2.01 ± 0.47 | 2.28 ± 0.25 | 0.000 |
Data are means ± SD, n (%), or median (interquartile range).
T2D: type 2 diabetic group, Ctrl: control group, HADS-D: Depression Subscale of Hospital Anxiety and Depression Scale, BMI: body mass index, WHR: waist-to-hip ratio, FPG: fasting plasma glucose, FIN: fasting insulin, HOMA-IR: homeostasis model assessment-insulin resistance [HOMA-IR = FIN (mIU/L) × FPG (mmol/L)/22.5], 8-OHdG: Human 8-hydroxy-desoxyguanosine.
*The total score of HADS-D is 21 and depression was identified as the score ≥10.